Dimerization through m-Xylylene Bridge: A Strategy for Enhanced Singlet Oxygen Generation in Benzothioxanthene Imide Photosensitizers
Yujie Feng , Andong Zhang , Tong Sun , Shanbei Zhang , Luyao Yang , Yixun Shu , Yahui Liu , Xiangwei Zhu , Zhishan Bo
Chinese Journal of Chemistry ›› 2026, Vol. 44 ›› Issue (9) : 1335 -1342.
Photodynamic antibacterial therapy (PDAT), with its advantages of high efficiency, controllability, and low drug resistance, has emerged as a promising research focus in the field of antibacterial treatment. Herein, we design an m-xylylene-bridged benzothioxanthene imide dimer (m-Dimer) to regulate molecular aggregation behavior. Notably, the aggregated m-Dimer exhibits a reduced singlet-triplet energy gap (ΔEST), which effectively facilitates the intersystem crossing (ISC) process and efficiently generates singlet oxygen (1O2) under visible light. Consequently, m-Dimer achieves exceptional antibacterial efficacy, eradicating both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) at a low concentration of 10 μM upon white-light irradiation. Moreover, its excellent photostability, straightforward synthesis, and low-cost underscore high potential for scalable PDAT applications.
Photodynamic / Aggregate / Dimer / Singlet oxygen / Antibacterial / m-Xylylene / Benzothioxanthene imide / Photosensitizer
2026 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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