One-Pot, Divergent Synthesis of Sulfonimidoyl- and Sulfondiimidoyl Fluorides
Wang-Fu Liang , Zhihua Wang , Ding-Bo Zeng , Hong Yan , Ke-Yin Ye
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (24) : 3617 -3622.
As the aza-isosteres of sulfonyl fluorides, sulfonimidoyl- and sulfondiimidoyl fluorides are versatile and robust SuFEx linkage agents, yet with limited synthetic accessibility. Herein, we report the straightforward, divergent synthesis of sulfonimidoyl- and sulfondiimidoyl fluorides from bench-stable, readily available sulfenamides and Selectfluor. The obtained sulfonyldiiminyl fluorides readily underwent versatile SuFEx reactions with various nucleophiles to afford various biologically interesting sulfondiimidoyl derivatives.
Synthetic methods / Click chemistry / SuFEx / Sulfenamides / Sulfonimidoyl fluorides / Sulfondiimidoyl fluorides
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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