CageCarbene-Ir Complex Enables Selective Alkylation and Alkenylation of Benzyl Alcohols with Alkyl Sulfones
Weikang Jiang , Xuebing Leng , Yanzhe Yang , Long Lu , Qilong Shen
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (24) : 3582 -3588.
A bis-carbene iridium catalyst with a unique structure, featuring a straightforward synthetic route and low-cost ligands was developed. This catalyst exhibits high catalytic activity in the Julia-type olefination reactions between sulfone compounds and benzyl alcohol derivatives, with catalyst loading reduced to as low as 0.5 mol%. Furthermore, by adjusting the reaction conditions, the resultant olefinic products can be further reduced in a single step to afford the corresponding alkane compounds. This study also explores the reaction mechanism, proposing a plausible catalytic cycle based on a series of control experiments.
Alkylation / Alkenylation / N-Heterocyclic carbene / Iridium / Dehydrogenative
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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