Rhodium-Catalyzed Intermolecular C–H Silylation of Indoles with Silacyclobutanes
Shengbo Xu , Mengxia Gong , Fen Wang , Xingwei Li
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (24) : 3522 -3528.
Silylation of C–H bond has been established to be an important strategy toward construction of complex organosilicons. Still, the state-of-the-art is mostly limited to intramolecular reactions or limited to employment of thiophenes or reactive arene reagents. Herein, rhodium-catalyzed intermolecular C–H silylation of indoles has been realized using silacyclobutanes as a silylating reagent, affording a variety of C2-silylated indoles. This chelation-assisted C–H silylation system proceeds well with a broad substrate scope with 100% atom-economy.
Rhodium / C−H bond activation / Indole / Silacyclobutane / Silylation
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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