Photoredox-Catalyzed Direct Decarboxylative Amination of Alkyl Carboxylic Acids Enabled by a Novel N-Centered Radical Scavenger
Changlei Zhu , Mengqing Zhang , Jiaxin Lin , Xiaoguang Bao , Jingjing Wu
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (24) : 3575 -3581.
Alkylamines play an important role in medicinal chemistry, while carboxylic acids are commonly found in many natural products and pharmaceuticals. In this study, we developed a direct photoredox-catalyzed decarboxylative amination of alkyl carboxylic acids using a novel N-centered radical scavenger. This method avoids pre-activation and transition-metal catalysts, allowing a diverse range of readily available carboxylic acids to be efficiently converted into medicinally valuable amines. Further mechanistic studies and DFT calculations were conducted to provide evidence for the proposed photoredox-catalyzed pathway. This protocol is operationally simple and has excellent functional group compatibility, which is likely to be of great use in synthetic chemistry
Photoredox-catalysis / Decarboxylative amination / Alkyl carboxylic acid / N-Centered radical scavenger
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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