Palladium-Catalyzed Tandem 1,6-Enyne Cyclization/Suzuki Reaction for the Synthesis of Diaryl Compounds
Yuanfang Wang , Junlong Tang , Wanqing Wu , Huanfeng Jiang
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (23) : 3119 -3124.
Herein, it is reported that a palladium/bidentate amine ligand cooperative catalytic system has been developed to achieve the intramolecular cyclization of 1,6-enyne coupled with a Suzuki cross-coupling reaction, successfully constructing a diaryl-substituted γ-butyrolactam skeleton. The tandem catalytic mechanism significantly enhances synthetic efficiency by circumventing the isolation and purification of intermediates required in traditional stepwise synthesis, demonstrating exceptional step economy. This method provides a novel modular strategy for the rapid assembly of bioactive diaryl-containing lactam compound libraries.
Palladium catalysis / Enyne / Cyclization / Suzuki coupling / Arylation / Difunctionalization / Step economy / γ-butyrolactam skeleton
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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