Pd-Catalyzed Regioselective Isomerization-Hydroformylation of Internal Olefins with HCO2H and N-Formylsaccharin
Wenlong Ren , Jinzi Huang , Jintao Ou , Yuan Shi , Yian Shi
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (23) : 3295 -3301.
This work describes an effective Pd-catalyzed isomerization-hydroformylation of internal olefins with HCO2H and N-formylsaccharin, providing a wide variety of linear aldehydes in up to 72% yield with up to 18 : 1 l/b ratio. The olefin substrate can bear various functional groups. Conjugated olefins can also be efficiently isomerized and hydroformylated. The reaction is easy to operate and requires no handling of CO and H2. To the best of our knowledge, the current process represents the first example for Pd-catalyzed efficient isomerization-hydroformylation process of internal olefins to predominately give linear aldehydes.
Aldehydes / C1 building blocks / Synthetic methods / Isomerization-hydroformylation / Internal olefins / Regioselective / HCO2H / N-Formylsaccharin
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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