Synthesis and Reaction of Pentafluorosulfanyl Chloride (SF₅Cl)

Abstract

The pentafluorosulfanyl (SF₅) group, characterized by its high electronegativity, lipophilicity and unique octahedral geometry, has the potential to modify the physicochemical properties of both pharmaceuticals and agrochemicals. Recently, pentafluorosulfanyl-containing compounds have garnered increasing attention, and big progress has been made in the development of novel synthetic strategies for these compounds. Central to these advancements is the exploration of synthesis and novel reaction of radical pentafluorosulfanylation reagents. This account provides an overview of the gas-reagent-free practical synthesis and new reaction of pentafluorosulfanyl chloride (SF₅Cl) developed by our group.

Keywords

Pentafluorosulfanylation / Pentafluorosulfanyl chloride / Fluorine chemistry / Radical / Synthetic method / Fluorine / Sulfur / Hypervalent compounds

RIGHTS & PERMISSIONS

2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH