Photoinduced Three-Component Carboimination of Alkenes to Access γ-Aminobutyric Acid Derivatives
Lu Tan , Weicai Li , Shijing Tu , Xinyu Zhong , Xinhao Li , Xi Du , Zhijie Zhang , Siping Wei , Dong Yi
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (19) : 2533 -2538.
Photoinduced Three-Component Carboimination of Alkenes to Access γ-Aminobutyric Acid Derivatives
The remarkable biological activities of γ-aminobutyric acid derivatives (GABAs) spurred the exploration of green and efficient synthetic methods to construct these scaffolds. Herein, we have developed a catalyst-free photoinduced strategy for the redox-neutral three-component carboimination of alkenes, enabling efficient and modular assembly of a wide range of γ-aminobutyric acid derivatives. Mechanistic studies indicate that this reaction is initiated with an electron donor-acceptor complex between deprotonated malonates and O-aryl oximes. Furthermore, the resulting products could be further converted to functionalized γ-lactam derivatives through an acidic lactamization process.
Electron donor-acceptor / γ-Aminobutyric acid / Three-component / Radical reactions / Malonates / Carboimination / Photocatalyst-free
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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