Nitric Oxide Encapsulation in Metal-Organic Cages via Physical Confinement
Chuang-Wei Zhou , Yi-Tong Liu , Xue-Zhi Wang , De-Bo Hao , Jie Pang , Zhao-Xia Lian , Yong-Liang Huang , Yan Wu , Yan Yan Li , Xue Li , Xiao-Ping Zhou , Dan Li
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (19) : 2525 -2532.
Nitric Oxide Encapsulation in Metal-Organic Cages via Physical Confinement
The stabilization of active molecules is significantly important for chemistry, especially for the bioactive molecules. In this work, we report the synthesis and characterization of three tetrahedral Fe4L6 cages, which are water-soluble and functionalized with or without PEG chains. All cages can physically trap NO molecules in their cavities to prevent a reaction with O2. Single-crystal X-ray diffraction (SCXRD), Griess assay, electron paramagnetic resonance (EPR) spectroscopy, and fluorescence assay demonstrate that NO molecules were encapsulated and stabilized by these cage molecules through the formation of host-guest supramolecules. These NO-loaded cages show high antibacterial activities for inhibiting Staphylococcus aureus and Escherichia coli, providing a convenient method for making antibiotic agents. Moreover, these PEG-functionalized cages exhibit excellent biocompatibility, providing a new strategy for developing materials for NO delivery in biomedical applications
Metal-organic cages / Nitric oxide / Host-guest chemistry / Physical confinement / Antibacterial materials
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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