A Near-Infrared Fluorescence Hypochlorite Probe for Imaging Atherosclerosis without Interference from Serum Protein and Microenvironment Factors
Shuangshuang Wei , Wenxuan Zhang , Qian Li , Hongyu Li , Zeli Yuan , Huimin Ma
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (19) : 2449 -2456.
A Near-Infrared Fluorescence Hypochlorite Probe for Imaging Atherosclerosis without Interference from Serum Protein and Microenvironment Factors
Atherosclerosis (AS), a chronic vascular lesion, constitutes the primary pathological basis for a variety of cardiovascular diseases that account for 85% of total cardiovascular mortality. The accurate identification of AS is of critical significance for early clinical diagnosis and therapeutic interventions for associated diseases. Herein, we report a changeable π-conjugated probe (ASOCl-1) capable of specific AS imaging with resistance to serum protein interference and microenvironmental perturbations. ASOCl-1 itself was non-conjugated and non-fluorescent. Upon the activation by inflammatory biomarker hypochlorite (OCl−), the probe underwent a molecular rearrangement to generate a near-infrared fluorophore oxazine, with environmental-insusceptible response and anti-interference from serum protein. ASOCl-1 has been used to image OCl− inside foam cells, a type of cell derived from macrophages at the AS sites. Most importantly, ASOCl-1 could achieve in vivo, ex vivo and slice imaging of AS mice. The satisfactory imaging performance and anti-interference capability of ASOCl-1 make it a potential tool for AS imaging diagnosis and disease progression monitoring.
Fluorescence probe / Atherosclerosis / Hypochlorite / Anti-interference / Accurate diagnosis
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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