Visible-Light-Driven Thiolate-Catalyzed Carbo-Carboxylation of Alkenes with CO2: Facile Synthesis of Oxindole-3-acetic Acid Derivatives
You-Yang Jiang , Zhen Chen , Yuan-Xu Jiang , Wen-Jing Zhu , Jin-Cheng Xu , Jian-Heng Ye , Wei Zhang , Da-Gang Yu
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (18) : 2341 -2346.
Visible-Light-Driven Thiolate-Catalyzed Carbo-Carboxylation of Alkenes with CO2: Facile Synthesis of Oxindole-3-acetic Acid Derivatives
Herein, we present a visible-light-driven carbo-carboxylation of alkenes with CO2 via catalytic electron donor-acceptor (EDA) complex activation. A variety of oxindole-3-acetic acid and derivatives were generated in moderate to excellent yields from N-arylacrylamides and CO2. Mechanistic studies revealed the formation of an EDA complex between catalytic thiolate and alkene. Notably, this redox-neutral reaction features mild, transition-metal and photocatalyst-free conditions, good functional group tolerance and broad substrate scope. Furthermore, the facile synthesis of key intermediates in natural products underscores the utility of this methodology.
Carbon dioxide / Visible light / Carbo-carboxylation / Electron donor-acceptor (EDA) complex / Oxindole-3-acetic acid derivatives / N-Arylacrylamides / Thiolate
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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