Diazaphospholene-Catalyzed 1,5-HAT of Aryl Halides to Access γ-Spirolactams
Manli Zhuang , Leyi Li , Mingying Li , Yuhui Lin , Jiapian Huang , Wei Xiao , Min Yang , Jie Wu
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (18) : 2313 -2317.
Diazaphospholene-Catalyzed 1,5-HAT of Aryl Halides to Access γ-Spirolactams
In the past decades, diazaphospholene hydrides (DAP-H) have emerged as powerful catalysts for a variety of reductive transformations. However, the radical processes with DAPs as catalysts are extremely rare. Herein, a DAP-catalyzed radical process of aryl halides to access γ-spirolactams through a XAT/1,5-HAT/radical addition/HAT process is presented. This reaction features metal-free conditions and broad functional group tolerance, leading to γ-spirolactams in good yields.
Diazaphospholenes / 1,5-HAT / Radical cyclization / Aryl radical / γ-Spirolactams / Cyclization / Alkynes / Alkenes
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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