Cobalt-Catalyzed Silyldifluoromethylamination of Styrenes withTMSCF2H and Nitrogen Nucleophiles
Fengxiang Zhu , Ni Wang , Xiao-Feng Wu
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (17) : 2193 -2198.
Cobalt-Catalyzed Silyldifluoromethylamination of Styrenes withTMSCF2H and Nitrogen Nucleophiles
Aminosilylalkanes are important motifs in bioactive molecules, yet methods for their direct incorporation remain limited. In particular, the efficient introduction of gem-difluoro groups–known to significantly modulate the physical, chemical, and biological properties of organic molecules–into aminosilylalkane remains a challenge. Herein, we report a cobalt-catalyzed silyldifluoromethylamination of styrenes using TMSCF2H and nitrogen nucleophiles. By employing readily available starting materials, a series of complex, highly functionalized aminosilyldifluoroalkane derivatives were synthesized in moderate to good yields. This methodology establishes a novel strategy for constructing organosilicon compounds, complementing existing synthetic approaches.
Cobalt / Silyldifluoromethyl-Amination / Styrenes / C–H bond activation / Three-component / Synthetic methods
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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