Intracellular Fate Tracking of DNA Nanostructures
Yubo Liu , Xia Liu , Linjie Guo , Lihua Wang , Jiang Li , Ying Zhu , Kai Jiao , Chunhai Fan
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (17) : 2245 -2260.
Intracellular Fate Tracking of DNA Nanostructures
DNA nanostructures, with their high structural programmability and excellent biocompatibility, have shown tremendous potential in biomedicine applications. This review provides an overview of the self-assembly principles underlying DNA nanostructures, with a particular focus on the current techniques for intracellular tracking, highlighting their advantages and limitations. Building on this foundation, the intracellular behaviors and fates of DNA nanostructures are discussed, along with their potential applications in biomedicine. Finally, future research directions are proposed, offering insights and guidance for the continued development of DNA nanostructures in biomedical fields.
DNA nanostructures / Intracellular fate / Tracking / Imaging technology / Biomedicine / Nucleic acids / Bioimaging / Drug carriers
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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