Sulfonated Phosphine-Palladium/Bisguanidinium Ion Pair Catalyzed Enantioselective Allylic Amination

Longyi Xi; Rajakili Selvam; Xu Chen; Juan Du; Govindasamy Sekar; Jun Song; Junmin Zhang; Choon-Hong Tan

doi:10.1002/cjoc.70047

Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (15) : 1813 -1818. DOI: 10.1002/cjoc.70047

Concise Report

Sulfonated Phosphine-Palladium/Bisguanidinium Ion Pair Catalyzed Enantioselective Allylic Amination

Author information +

History +

PDF

Abstract

In this study, we successfully developed ion pair catalysts consisting of chiral bisguanidinium (BG) cations and non-chiral sulphonated phosphine-palladium complexes as counterions. These ion pairs catalyzed allylic alkylation reactions with excellent enantioselectivities. Furthermore, these reactions can be easily performed on a gram-scale, demonstrating their potential for industrial applications. We were able to obtain ¹H NMR of the ion pair catalyst and identified the ³¹P NMR of the sulphonated phosphine-palladium complex.

Keywords

Bisguanidinium / Anion phosphine ligand / Ion pair strategy / Palladium catalysis / Enantioselective amination

Cite this article

Download citation ▾

Longyi Xi, Rajakili Selvam, Xu Chen, Juan Du, Govindasamy Sekar, Jun Song, Junmin Zhang, Choon-Hong Tan. Sulfonated Phosphine-Palladium/Bisguanidinium Ion Pair Catalyzed Enantioselective Allylic Amination. Chinese Journal of Chemistry, 2025, 43(15): 1813-1818 DOI:10.1002/cjoc.70047