Synthesis of 1,7-Annulated Indazole Derivatives via Bifunctional Brønsted Base Catalyzed Cascade Reaction
Pengcheng Shao , Weiwu Ren
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (12) : 1373 -1378.
Synthesis of 1,7-Annulated Indazole Derivatives via Bifunctional Brønsted Base Catalyzed Cascade Reaction
A novel method for the asymmetric synthesis of 1,7-annulated indazoles has been developed via bifunctional Brønsted base catalyzed cascade reaction. This process enabled the formation of multiple chiral centers including a quaternary carbon center in high yields with excellent diastereoselectivities and enantioselectivities. The reaction exhibited broad functional group tolerance and mild reaction conditions.
Asymmetric synthesis / 1,7-Annulated indazole / Bifunctional Brønsted base / Cascade reaction / Aldimine / Azlactone / N-Heterocycles
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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