Palladium-Catalyzed Carbonylation of ortho-Alkenyl Iodobenzenes for the Construction of 3-Arylindenones
Minxiu Qian , Lingyun Yao , Zhi Li , Xusheng Shao , Quannan Wang , Wei-Ping Deng
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (10) : 1135 -1140.
Palladium-Catalyzed Carbonylation of ortho-Alkenyl Iodobenzenes for the Construction of 3-Arylindenones
We developed a novel Pd-catalyzed carbonylation of ortho-alkenyl iodobenzenes with CO, affording a diverse array of 3-arylindenones in good to excellent yields (up to 94% yield). This methodology exhibits broad substrate scope and good functional group compatibility. The synthetic utility was demonstrated by a gram-scale reaction, diverse product derivatizations, and the preparation of an intermediate for a PPARγ agonist.
Pd-catalyzed / Carbonylation / Indenones / Methodology and reactions / Carbon monoxide / C1 building blocks
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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