Divergent Synthesis of Four Types of Fused N-Containing Heterocycles via Oxidative Multi-Component Cyclization Reaction
Xiaoshuang Guo , Maozhong Miao , Peng Zhao , Yongmin Ma
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (9) : 1009 -1014.
Divergent Synthesis of Four Types of Fused N-Containing Heterocycles via Oxidative Multi-Component Cyclization Reaction
An atmospheric-oxygen-mediated four-component reaction was developed for the divergent synthesis of pyrazolo[1,5-a]pyrimidine and pyrazolo[3,4-b]pyridine derivatives from readily available alcohols and 3-aminopyrazoles. In this transformation, atmospheric oxygen serves as the green oxidant, promoting alcohols as equivalent aldehydes for the synthesis of four types of N-containing heterocycles (> 40 examples). Remarkably, the transformation features metal-free and molecular diversity.
Divergent synthesis / C—OH bonds / Atmospheric oxygen / Cyclization / C—C coupling / N-Heterocycles
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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