Photoinduced Metal-/Additive-Free Difluoromethylation of N-Heteroaromatics
Congjun Zhu , Yangyang Shen , Tao Guo , Qing Yang , Dongpu Zhao , Huiqing Yang , Jin Xie
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (8) : 905 -910.
Photoinduced Metal-/Additive-Free Difluoromethylation of N-Heteroaromatics
Herein, we report a photo-induced, metal-/additive-free protocol for the difluoromethylation of N-heteroaromatics with [bis(difluoroacetoxy)iodo]benzene as the difluoromethylation reagent. The protocol affords difluoromethylated N-heteroaromatics in moderate to good yield (up to 91%). The transformation is compatible with a wide range of substrates and has good tolerance towards various functional groups. Moreover, the synthetic value of this method is further demonstrated by applications in gram-scale synthesis and the late-stage functionalization of biologically important molecules.
Difluoromethylation / N-Heterocycles / Metal-/additive-free / Photoinduced / Radical reaction
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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