Biomass-Derived Cu-Catalyzed General C—X (X = C, N, O) Bond Formation: Carbenoid Insertion Reactions of C—H, N—H, O—H Bond and Late-stage Functionalization of Drug Molecules
Fuhua Qin , Wenxuan Xue , Conghui Tang
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (8) : 916 -924.
Biomass-Derived Cu-Catalyzed General C—X (X = C, N, O) Bond Formation: Carbenoid Insertion Reactions of C—H, N—H, O—H Bond and Late-stage Functionalization of Drug Molecules
The development of sustainable and efficient catalytic systems for the formation C—C, C—N, C—O bonds is a fundamental goal in modern synthetic chemistry. We present a biomass-derived Cu/Chitosan-800 catalyst that facilitates a range of carbenoid insertion reactions into C—H, N—H, and O—H bonds. This catalyst demonstrates remarkable activity, enabling the functionalization of diverse substrates, including the late-stage modification of drug molecules with up to 95% yield and good recyclability. Our findings highlight the catalyst's potential in advancing environmentally friendly chemical transformations, offering a promising tool for pharmaceutical synthesis and organic synthesis.
Heterogeneous catalysis for organic synthesis / Copper catalysis / Carbene insertion reaction / Chitosan / Late-stage functionalization / 3d transition metals / Synthetic methods / Heterogeneous catalysis
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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