Chiral Porous Frameworks for Enantioselective Separation and Asymmetric Catalysis
Bing Yan , Jin-Hui Song , Da-Long Zhang , Zong-Jie Guan , Yu Fang
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (9) : 1078 -1089.
Chiral Porous Frameworks for Enantioselective Separation and Asymmetric Catalysis
The preparation and resolution of chiral molecules hold significant importance in scientific and industrial domains, such as drug development and manufacturing. In recent years, chiral porous frameworks have attracted increasing attention in asymmetric catalysis and enantiomer resolution due to their excellent performance. The metal-organic frameworks (MOFs), covalent organic frameworks (COFs), porous organic cages (POCs), and porous coordination cages (PCCs) are important representative of the porous framework family. Significantly, chirality can be easily introduced into these framework materials through simple bottom-up or post-modification methods, thereby promoting their applications related to chirality. In this review, we systematically summarize the synthesis strategies of four classes of chiral framework materials and their applications in asymmetric catalysis and enantiomeric resolution. Finally, we present some perspectives on the future development in chiral porous frameworks.
Chirality / Crystallization / Chiral resolution / Synthesis design / Asymmetric catalysis
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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