Electrochemical N–H Methylsulfoxidation of Sulfoximines with DMSO
Qing-Ru Zhu , Gen Liu , Yongxiang Wang , Zhubing Xiao , Hui Gao , Pei-Long Wang
Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (8) : 897 -904.
Electrochemical N–H Methylsulfoxidation of Sulfoximines with DMSO
The N–H methylsulfoxidation of sulfoximines using DMSO as a methylsulfinyl source, induced by electrochemistry, has been developed. This method is the first example of an electrochemical reaction in which DMSO serves as a methylsulfinyl source. Unlike previous electrochemical reactions involving DMSO as a substrate, which exclusively proceed via radical mechanisms, this reaction follows an S-cation pathway. A wide range of N-methylsulfinyl sulfoximines were successfully obtained.
Electrochemistry / Dimethyl sulfoxide / Sulfoximine / Methylsulfoxidation / Defluorination / Cations / Synthetic methods / Isotopes
2025 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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