Catalyst-Free, Radical Tri- and Difluoromethylation of Isocyanides and N-Arylacrylamides Using Rotating Magnetic Field and Metal Rods

Xuliang Han; Haodong Liu; Xiaomei Feng; Fuchao Jia; Zengdian Zhao; Xinjin Li

doi:10.1002/cjoc.202400854

Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (2) : 155 -160. DOI: 10.1002/cjoc.202400854

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Catalyst-Free, Radical Tri- and Difluoromethylation of Isocyanides and N-Arylacrylamides Using Rotating Magnetic Field and Metal Rods

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Abstract

Comprehensive Summary:The pursuit of sustainable and environmentally benign synthetic methods continues to challenge organic chemists. Herein, we introduce a magnetoredox system for tri- and difluoromethylation of isocyanides and N-arylacrylamides using a rotating magnetic field and steel rods. This magnetoredox approach enables facile synthesis of functionalized phenanthridines and oxindoles without the need for catalysts and additives under mild conditions. Such a system potentially represents an attractive strategy for selective formation of bonds through multifaceted regulation of magnetic intensity, rotating frequency, and rod size.

Keywords

Trifluoromethylation / Difluoromethylation / Radical / Single-electron transfer / Catalyst-free / Magnetic field / Electromagnetic induction / Isocyanides

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Xuliang Han, Haodong Liu, Xiaomei Feng, Fuchao Jia, Zengdian Zhao, Xinjin Li. Catalyst-Free, Radical Tri- and Difluoromethylation of Isocyanides and N-Arylacrylamides Using Rotating Magnetic Field and Metal Rods. Chinese Journal of Chemistry, 2025, 43(2): 155-160 DOI:10.1002/cjoc.202400854