Recent Advances of Terpenoids with Intriguing Chemical Skeletons and Biological Activities

Yi Zang; Ruo-nan Sun; Ran-qi Feng; Hong-hui Zhu; Xu-wen Li

doi:10.1002/cjoc.202400697

Chinese Journal of Chemistry ›› 2025, Vol. 43 ›› Issue (4) : 443 -469. DOI: 10.1002/cjoc.202400697

Recent Advances

Recent Advances of Terpenoids with Intriguing Chemical Skeletons and Biological Activities

Yi Zang ¹^,^†
, Ruo-nan Sun ²^,³^,⁴
, Ran-qi Feng ²^,³^,⁴
, Hong-hui Zhu ¹^,^†
, Xu-wen Li ²^,³^,^†

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Abstract

Terpenoids are a large and diverse family of secondary metabolites that have gained more attention from chemists and pharmacologists for their intriguing skeletons and broad biological activities, including anti-inflammatory, antitumoral, antimicrobial, and anti-viral effects. Based on the previous reviews, this review comprehensively summarized recent advances on bioactive terpenoids, focusing on their intriguing structural features and promising biological activities, covering literature from 2020 to 2023. In this review, 532 terpenoids with remarkable chemical architectures and biological properties are classified into sesquiterpenoids (142), diterpenoids (129), sesterterpenoids (24), triterpenoids (52), and meroterpenoids (185), that were isolated from terrestrial and marine resources. This review would provide a reference for researchers to rapidly discover the interesting terpenoids for further study as promising drug leads.

Keywords

Natural products / Terpenoids / Novel structures / Biological activity / Drug discovery

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Yi Zang, Ruo-nan Sun, Ran-qi Feng, Hong-hui Zhu, Xu-wen Li. Recent Advances of Terpenoids with Intriguing Chemical Skeletons and Biological Activities. Chinese Journal of Chemistry, 2025, 43(4): 443-469 DOI:10.1002/cjoc.202400697