Radicals as Chiral Catalysts for Asymmetric Radical Cyclization Reactions
Quan-Qing Zhao , Min Gu , Jia-Rong Chen
Chinese Journal of Chemistry ›› 2024, Vol. 42 ›› Issue (19) : 2412 -2416.
Radicals as Chiral Catalysts for Asymmetric Radical Cyclization Reactions
Due to the innate highly reactive properties and short life-time, organic free radicals can often serve as promoters or intermediates to engage in various radical transformations, which are often otherwise difficult to access by ionic pathway-based mechanisms. With the evolvement of radical chemistry, chiral radical catalyzed-transformations have recently emerged as an attractive and robust platform for synthesis of chiral molecules of interest. Herein, we highlight several creative and strategic advances in chiral radical catalyst design, cyclization reaction achievements, and future challenges.
Chiral radical catalysis / Radical cyclization / Thiyl radical / Boryl radical / Asymmetric synthesis
2024 SIOC, CAS, Shanghai, & WILEY-VCH GmbH.
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