Skeletal Editing of Cyclic Molecules Using Nitrenes

Yi-An Xu; Shao-Hua Xiang; Jin-Teng Che; Yong-Bin Wang; Bin Tan

doi:10.1002/cjoc.202400342

Chinese Journal of Chemistry ›› 2024, Vol. 42 ›› Issue (21) : 2656 -2667. DOI: 10.1002/cjoc.202400342

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Skeletal Editing of Cyclic Molecules Using Nitrenes

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Abstract

Comprehensive Summary: Nitrenes, as neutral monovalent nitrogen-centered molecular species, can insert into various bond or remove nitrogen atoms from amines. Nitrene assisted single-atom skeletal editing, discovered decades ago, provides an efficient approach for the precise alteration of cyclic skeletons. In this review, we briefly summarize early studies on skeletal editing of cyclic frameworks involving nitrene species, and introduce several recent important advances systematically.

Keywords

Nitrenes / Skeletal Editing / Cyclic Compounds / Atom exchange / Late-stage modification

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Yi-An Xu, Shao-Hua Xiang, Jin-Teng Che, Yong-Bin Wang, Bin Tan. Skeletal Editing of Cyclic Molecules Using Nitrenes. Chinese Journal of Chemistry, 2024, 42(21): 2656-2667 DOI:10.1002/cjoc.202400342