Visible-Light-Induced Domino Cyclization to Access Pyrido[2, 3-d]pyrimidine-2, 4-diones via a Radical-Polar Crossover Reaction

Wanqing Zuo; Yu Cheng; Zhizhen Zhu; Lingling Zuo; Xiao Geng; Zhifang Li; Lei Wang

doi:10.1002/cjoc.202400315

Chinese Journal of Chemistry ›› 2024, Vol. 42 ›› Issue (19) : 2346 -2350. DOI: 10.1002/cjoc.202400315

Concise Report

Visible-Light-Induced Domino Cyclization to Access Pyrido[2, 3-d]pyrimidine-2, 4-diones via a Radical-Polar Crossover Reaction

Author information +

History +

PDF

Abstract

Catalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing. We now report a radical-polar crossover (RPC)-enabled three-component cyclization of bromodifluoroalkyls with enaminones and 6-aminouraciles via a visible-light-induced domino cyclization. The reaction exhibited a broad substrate scope (> 40 examples) including complex molecules, which highlighted the utility of this strategy for the construction of a library of bioactive analogs.

Keywords

Photocatalysis / Heterocycles / Radicals / Bromodifluoroalkyls / 6-Aminouraciles / Enaminones

Cite this article

Download citation ▾

Wanqing Zuo, Yu Cheng, Zhizhen Zhu, Lingling Zuo, Xiao Geng, Zhifang Li, Lei Wang. Visible-Light-Induced Domino Cyclization to Access Pyrido[2, 3-d]pyrimidine-2, 4-diones via a Radical-Polar Crossover Reaction. Chinese Journal of Chemistry, 2024, 42(19): 2346-2350 DOI:10.1002/cjoc.202400315