Photochemical Radical Cascade 6-endo Cyclization of Dienes with α-Carbonyl Bromides for the Synthesis of Six-Membered Benzo-Fused Lactams
Jia-Li Sui , Yang Guo , Bi-Quan Xiong , Ke-Wen Tang , Peng-Fei Huang , Yu Liu , Jin-Heng Li
Chinese Journal of Chemistry ›› 2024, Vol. 42 ›› Issue (19) : 2323 -2328.
Photochemical Radical Cascade 6-endo Cyclization of Dienes with α-Carbonyl Bromides for the Synthesis of Six-Membered Benzo-Fused Lactams
A novel visible-light-induced radical cascade 6- endo cyclization of dienes ( N-(2-vinylphenyl)acryl amides) is developed utilizing α-carbonyl bromides as alkyl reagents. This approach affords an efficient way for synthesizing six-membered benzo-fused lactam derivatives with chemo- and regio-selectivity and good functional group tolerance. Primary, secondary, and tertiary bromides are well-compatible with this cascade cyclization reaction.
Visible-light-induced reaction / Cyclization / Transition-metal-free / Nitrogen heterocycles / α-Carbonyl bromides / Lactams / Alkylation / Radical reactions / Reduction
2024 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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