Streptavidin-Biotin Complexes as Tools for Modulating an Important DNA Epigenetic Modification

Yongjie Liu; Xinyan Xu; Xingyu Liu; Wei Xiong; Qianqian Qi; Yuanyuan Zhang; Jinxuan Hou; Tian Tian; Xiang Zhou

doi:10.1002/cjoc.202400236

Chinese Journal of Chemistry ›› 2024, Vol. 42 ›› Issue (18) : 2166 -2172. DOI: 10.1002/cjoc.202400236

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Streptavidin-Biotin Complexes as Tools for Modulating an Important DNA Epigenetic Modification

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Abstract

DNA 5-formylcytosine (5fC) is a prominent epigenetic modification within biological systems. Recent investigations have shed light on its pivotal role in governing cell fate, gene expression, and disease pathways. However, our comprehension of the precise control of the 5fC site structure to influence its functionality remains limited. In this study, we have successfully achieved precise control over 5fC activity by harnessing the interaction between streptavidin and biotin. This research underscores the potential application of interactions between biomacromolecules and small molecules in advancing the field of DNA epigenetic functional regulation.

Keywords

Epigenetic modification / Biotin / Streptavidin / Selectivity / Regulation

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Yongjie Liu, Xinyan Xu, Xingyu Liu, Wei Xiong, Qianqian Qi, Yuanyuan Zhang, Jinxuan Hou, Tian Tian, Xiang Zhou. Streptavidin-Biotin Complexes as Tools for Modulating an Important DNA Epigenetic Modification. Chinese Journal of Chemistry, 2024, 42(18): 2166-2172 DOI:10.1002/cjoc.202400236