Ru(II)-Catalyzed Selective C—H Alkynylation of Isoquinolones, Quinazolones and Phthalazinones with Bromoalkynes

Quan-Jian Luo; Han-Chi Wang; Jing Zhang; Jin-Heng Li; Bo Sun

doi:10.1002/cjoc.202400107

Chinese Journal of Chemistry ›› 2024, Vol. 42 ›› Issue (15) : 1686 -1690. DOI: 10.1002/cjoc.202400107

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Ru(II)-Catalyzed Selective C—H Alkynylation of Isoquinolones, Quinazolones and Phthalazinones with Bromoalkynes

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Abstract

A new, selective Ru(II)-catalyzed alkynylation reaction of isoquinolones, quinazolones and phthalazinones with readily available bromoalkynes has been developed. This reaction enables the selective construction of a new C(sp ²)-C(sp) bond through C—H activation and C—Br functionalization, and offers an effective and selective route to synthesizing highly valuable alkynylated isoquinolone, quinazolone and phthalazinone derivatives with a wide substrate scope and high selectivity.

Keywords

Ru(II) / Alkynylation / Isoquinolones / Bromoalkynes / Heterocyclic compounds / C—H activation / C—C coupling / Synthetic methods

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Quan-Jian Luo, Han-Chi Wang, Jing Zhang, Jin-Heng Li, Bo Sun. Ru(II)-Catalyzed Selective C—H Alkynylation of Isoquinolones, Quinazolones and Phthalazinones with Bromoalkynes. Chinese Journal of Chemistry, 2024, 42(15): 1686-1690 DOI:10.1002/cjoc.202400107