Ru(II)-Catalyzed Selective C—H Alkynylation of Isoquinolones, Quinazolones and Phthalazinones with Bromoalkynes
Quan-Jian Luo, Han-Chi Wang, Jing Zhang, Jin-Heng Li, Bo Sun
Ru(II)-Catalyzed Selective C—H Alkynylation of Isoquinolones, Quinazolones and Phthalazinones with Bromoalkynes
A new, selective Ru(II)-catalyzed alkynylation reaction of isoquinolones, quinazolones and phthalazinones with readily available bromoalkynes has been developed. This reaction enables the selective construction of a new C(sp2)-C(sp) bond through C—H activation and C—Br functionalization, and offers an effective and selective route to synthesizing highly valuable alkynylated isoquinolone, quinazolone and phthalazinone derivatives with a wide substrate scope and high selectivity.
Ru(II) / Alkynylation / Isoquinolones / Bromoalkynes / Heterocyclic compounds / C—H activation / C—C coupling / Synthetic methods
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