Recent Advances in the Electrochemical Defluorinative Transformations of C—F Bonds
Qinhui Wan , Rui-Xue Liu , Zhongyi Zhang , Xia-Die Wu , Zhong-Wei Hou , Lei Wang
Chinese Journal of Chemistry ›› 2024, Vol. 42 ›› Issue (16) : 1913 -1928.
Recent Advances in the Electrochemical Defluorinative Transformations of C—F Bonds
Comprehensive Summary: Organic fluorine compounds are ubiquitous and pivotally important organic molecules, yet their activation and transformation have long been a formidable challenge due to the high energy and low reactivity of C—F bonds. Organic electrosynthesis, an environmentally benign synthetic method in organic chemistry, enables a myriad of chemical transformations without the need for external redox reagents. In recent years, organic electrochemistry has emerged as a powerful tool for achieving the activation and transformation of C—F bonds in fluorine-containing compounds. This review aims to succinctly recapitulate the latest advancements in the electrochemical defluorinative transformations of C—F bonds and to delve into the reaction design, mechanistic insights, and developmental prospects of these methods.
Key Scientists: In 1959, Lund was the first to pioneer the electroreduction of CF3 to CH3 group. Electrochemistry has lately provided new opportunities for efficient conversion of organic fluorides. In 2020, Zhou and coworkers discovered the electrochemical defluorinative carboxylation of α-CF3 alkenes. Lambert and colleagues reported electrophotocatalytic defluorinative amination of aryl fluorides. Electrochemical hydrodefluorination of trifluoromethylketones was developed by Lennox and coworkers in 2021. In the same year, Wang and Guo disclosed electrochemical radical defluorinative alkylation of α-CF3 alkenes with Katritzky salts as the alkyl radical precursors. Subsequently, Wu and Liao described a transition-metal-free, site-selective C—F arylation of polyfluoroarenes with (het)arenes using paired electrophotocatalysis. In 2023, numerous efforts were made to achieve electrochemical C—F bond activation. Xia and Guo developed an organoboron-controlled method for the chemoselective electrochemical sequential (deutero)hydrodefluorination of trifluoroacetamides.
Organic electrochemistry / Electroreduction / Defluorination / C—F bond activation / Organic fluorine compounds
2024 SIOC, CAS, Shanghai, & WILEY-VCH GmbH
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