Mean Residual Life Causal Models for Survival Data with a Binary Instrumental Variable

Abstract

The causal effect of a treatment on a survival outcome is often of fundamental interest in scientific investigations. In the presence of unmeasured confounding, the instrumental variable (IV) is a valuable tool for estimating causal effects. In this article, we focus on modeling and inferring a family of generalized mean residual life (MRL) causal models, which are easily interpretable, for censored data. Utilizing a special characterization of the binary IV, we propose weighted estimating equations to estimate treatment effect and regression coefficients in MRL casual models. The weights are estimated using either logistic regression or kernel smoothing techniques. We establish the asymptotic properties of the proposed estimators and conduct extensive simulation studies to evaluate the finite sample performance. Finally, the proposed approach is applied to a dataset from the US Renal Data System to evaluate the causal effect of peritoneal dialysis in end-stage renal disease patients.

Keywords

Causal treatment effect / Censored data / Estimating equations / Instrumental variable / Mean residual life model / 62N01 / 62N02

Funding

National Natural Science Foundation of China(71931004)

RIGHTS & PERMISSIONS

School of Mathematical Sciences, University of Science and Technology of China and Springer-Verlag GmbH Germany, part of Springer Nature