Cancer Communications >

2024 , Vol. 44 >Issue 2: 273 - 277

DOI: https://doi.org/10.1002/cac2.12485

The SARS-CoV-2 spike protein induces lung cancer migration and invasion in a TLR2-dependent manner

  • Mi-Jeong Kim 1 ,
  • Ji Young Kim 1 ,
  • Ji Hye Shin 1 ,
  • Juhee Son 1 ,
  • Yeeun Kang 1 ,
  • Soo-Kyung Jeong 2 ,
  • Duk-Hwan Kim 3 ,
  • Kyun-Hwan Kim 4 ,
  • Eunyoung Chun , 2 ,
  • Ki-Young Lee , 1,5
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  • 1. Department of Immunology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea
  • 2. Research and Development Center, CHA Vaccine Institute, Seongnam-si, Republic of Korea
  • 3. Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea
  • 4. Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea
  • 5. Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Samsung Medical Center, Sungkyunkwan University, Seoul, Republic of Korea
chun.eunyoung@gmail.com
thylee@skku.edu

Received date: 12 Mar 2023

Revised date: 04 Sep 2023

Accepted date: 07 Sep 2023

Published date: 20 Feb 2024

Copyright

2023 2023 The Authors. Cancer Communications published by John Wiley & Sons Australia, Ltd. on behalf of Sun Yat-sen University Cancer Center.
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Cite this article

Mi-Jeong Kim , Ji Young Kim , Ji Hye Shin , Juhee Son , Yeeun Kang , Soo-Kyung Jeong , Duk-Hwan Kim , Kyun-Hwan Kim , Eunyoung Chun , Ki-Young Lee . The SARS-CoV-2 spike protein induces lung cancer migration and invasion in a TLR2-dependent manner[J]. Cancer Communications, 2024 , 44(2) : 273 -277 . DOI: 10.1002/cac2.12485

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Robilotti EV, Babady NE, Mead PA, Rolling T, Perez-Johnston R, Bernardes M, et al. Determinants of COVID-19 disease severity in patients with cancer. Nat Med. 2020;26(8):1218–1223.

2
Liang W, Guan W, Chen R, Wang W, Li J, Xu K, et al. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020;21(3):335–337.

3
Khan S, Shafiei MS, Longoria C, Schoggins JW, Savani RC, Zaki H. SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway. Elife. 2021;10:e68563.

4
Zhou Z, Ren L, Zhang L, Zhong J, Xiao Y, Jia Z, et al. Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients. Cell Host & Microbe. 2020;27:883–890.

5
Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181:271–280.

6
Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, et al. Multiplex genome engineering using CRISPR/Cas systems. Science. 2013;339(6121):819–823.

7
Min Y, Kim MJ, Lee S, Chun E, Lee KY. Inhibition of TRAF6 ubiquitin-ligase activity by PRDX1 leads to inhibition of NFKB activation and autophagy activation. Autophagy. 2018;14(8):1347–1358.

8
Kim JY, Kim MJ, Lee JS, Son J, Kim DH, Lee JS, et al. Stratifin (SFN) regulates lung cancer progression via nucleating the Vps34-BECN1-TRAF6 complex for autophagy induction. Clin Transl Med. 2022;12(6):e896.

9
Kim MJ, Lee JS, Kim JY, Choi B, Son J, Min Y, et al. CRBN is downregulated in lung cancer and negatively regulates TLR2, 4 and 7 stimulation in lung cancer cells. Clin Transl Med. 2022;12(9):e1050.

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