Recent progress of collagen-based hydrogels for wound healing: a review

Abstract

Wounds caused by trauma, burns, diabetes, and surgery have threatened human health, and wound management has become a serious clinical challenge and economic burden. Collagen-based hydrogels have good biological activity, biocompatibility, and biodegradability, which make them have broad application prospects as wound dressings in different stages of wound healing and different types of wound healing. In this paper, the advantages and composition characteristics of collagen-based hydrogel dressings and their function mechanism in different wound healing processes such as hemostasis, inflammatory, proliferation, and remodeling are systematically reviewed. To summarize, the main molecular mechanisms of collagen-based hydrogel dressings include the provision of abundant nutrients at various stages, modulation of related cytokines (e.g., CD34, bFGF, and CTGF), inducement of signaling pathways (such as TGF-β/Smad, PI3K/Akt/mTOR), and promotion of the synthesis of ECM components, especially collagen. Thus, throughout the wound healing process, collagen-based hydrogel dressings can accelerate wound hemostasis, reduce inflammation, promote cell proliferation (especially of fibroblasts), aid in angiogenesis, enhance collagen synthesis, accelerate granulation tissue formation and re-epithelialization, and remodel the cytoplasmic matrix, ultimately leading to wound closure. Furthermore, this review discusses the existing problems in clinical application and scale production and outlines the future of development directions in the researches of collagen-based hydrogel dressings combining innovative wound treatment technologies, preparation technologies, and structural design methods, in order to inspire more new advancement and progress.

Graphic Abstract

Keywords

Collagen / Gelatin / Peptide / Hydrogel / Wound healing / Function / Mechanism

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Funding

National Natural Science Foundation of China(No. 22078207)

Sichuan Science and Technology Program(No. 2023YFG0250)

RIGHTS & PERMISSIONS

The Author(s)