Functionalized collagen-based biomaterials via self-assembly: implications for gastrointestinal health

Abstract

Collagen, one of the most abundant proteins in human physiology, maintains the morphology and structure of skin and tissues, serving as an important raw material for the repair of damaged tissues. Collagen's widespread application in biomedicine stems from its myriad beneficial properties, including its diverse sourcing, exceptional biocompatibility, sustainability, low immunogenicity, porous nature, and biodegradability. In addition, collagen can self-assemble with other molecules through multiple interactions to form a variety of structures, thereby enhancing its biological functions. In recent years, gastrointestinal diseases have attracted much attention due to their high prevalence and complexity. In this context, collagen-based biomaterials, such as collagen scaffolds and hydrogels, have demonstrated an important role in the treatment of gastrointestinal diseases. This review aims to summarize the research progress of collagen-based biomaterials for the treatment of gastrointestinal diseases in recent years, with a focus on their self-assembly properties and application advantages. Our goal is to explore innovative methods for producing collagen-based biomaterials, aiming to broaden their potential applications and enhance precise therapeutic effects to expand their clinical applications.

Graphical Abstract

Keywords

Collagen-based biomaterials / Self-assembly / Gastrointestinal diseases / Biocompatibility / Therapeutic applications

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Funding

National Key R&D Program of China(2022YFA0912800)

National Excellent Young Scientists Fund(00308054A1045)

National Natural Science Foundation of China(22178233)

Talents Program of Sichuan Province

Double First Class University Plan

State Key Laboratory of Polymer Materials Engineering(sklpme 2020-03-01)

Sichuan Tianfu Emei Project(2022-EC02-00073-CG)

Sichuan Science and Technology Program(2022YFN0070)

RIGHTS & PERMISSIONS

The Author(s)