Anaesthetic exposure during oocyte pickup: Comparative effects of fentanyl-propofol versus parecoxib sodium on neonatal outcomes

Abstract

Objective: To evaluate the neonatal outcomes of fentanyl-propofol anaesthesia versus parecoxib sodium analgesia regimens used during oocyte pickup (OPU).

Methods: Couples who underwent assisted reproductive technology (ART) treatment at the Reproductive Genetics Department of the First Affiliated Hospital of Kunming Medical University from April 2016 to February 2022 were enrolled in this study. The participants were divided into two groups based on the anaesthesia protocols used during OPU: parecoxib sodium analgesia (n=1 124) and fentanyl-propofol anaesthesia (n=1 190). Neonatal outcomes were systematically compared between these groups, with infant birth weight as the primary outcome.

Results: A total of 2 314 couples were included in the study. After adjustment for confounders, the median birth weight of infants was significantly lower in the parecoxib sodium group than in the fentanyl-propofol group [3100 g (interquartile range: 2850-3400) vs 3200 g (IQR: 2900-3450), adjusted β= -50.9 (95% CI: -89.4 to -12.3), P=0.01]. This weight difference remained particularly significant in male infants [3120 g vs 3200 g, β= -63.4 (95% CI: -119.2 to -7.5), P=0.03], whereas no significant difference was observed in female infants after adjustment [β= -27.9 (95% CI: -82.9 to 27.1), P>0.05].

Conclusion: Neonates born after OPU with parecoxib sodium weighed significantly less than those delivered under fentanyl- propofol, and this difference was confined to male infants.

Keywords

Anaesthesia / Assisted reproductive technology / Infertility / Pregnancy outcomes

Conflict of interest statement

The authors declare that there are no conflict of interest.

Acknowledgements

Professional English language editing support provided by AsiaEdit (asiaedit.com).

Funding

This study was financially supported by the First-Class Discipline Team of Kunming Medical University(2024XKTDTS02), Yunnan Key Laboratory of Organ Transplantation (No. 202449CE340016) and Zhejiang Provincial Public Welfare Technology Applied Research (LGD22C090002).

Data availability statement

The datasets generated and/or analysed during the current study are not publicly available to protect patient privacy and maintain research integrity but are available from the corresponding author on reasonable request.

Authors’ contributions

Shiyu Yang conducted the statistical analysis and wrote the main manuscript text. Jiahe Tian and Xiufang Gui assisted with the analysis and edited the draft manuscript. Longda Wang provided input on the design and revision. Kaiming Yuan and Shuhua Zhao designed and directed the entire study and extracted all data from medical records. All authors have read and approved the final version.

Publisher’ s Note

The Publisher of the Journal remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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