Case report: Lumpy skin disease case analysis in central China

Abstract

Lumpy skin disease (LSD), a highly contagious viral infection caused by Lumpy Skin Disease Virus (LSDV), has caused severe economic losses. We analyzed three representative outbreaks in 2024, combining clinical, histopathological, serological, and molecular data to refine regional control strategies. According to our findings, affected cattle presented with generalized cutaneous nodules, fever and peripheral edema; one-third of in-contact animals remained clinically normal yet seroconverted within ten days. Antibody titers peaked at approximately 20 d post-onset and were accompanied by persistent viral DNA in saliva, ocular secretions and skin scabs. Histology revealed alveolar septal edema, hepatocellular ballooning, and glomerular necrosis, whereas biochemical profiling revealed hypalbuminemia, hyperglobulinemia, and elevated alanine aminotransferase in one patient. Immunohistochemistry revealed intense LSDV antigen in the spleen, alveolar septa of the lung, and throughout the dermis of the skin nodules, identifying these tissues as the most reliable diagnostic targets. The combined findings confirm active viral replication in cutaneous, respiratory and lymphoid tissues, highlight the occurrence of subclinical infection and underscore the value of paired serology and PCR for herd screening. Prompt isolation, vector control and vaccination with homologous capripox vaccines are recommended to curtail transmission and economic impact.

Keywords

Lumpy skin disease virus / Pathology / Immunohistochemistry / Disease control and prevention

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Funding

National Key Research and Development Program of China(2022YFD1800701)

LIJIANG Joint Expert Studio of Guo Aizhen, Zhang Meiyan and Li Weijuan(20233335C02)

the Chinese Agricultural Research System of MOF and MARA((#CARS-37))

RIGHTS & PERMISSIONS

The Author(s)