Systemic Mycobacterium caprae infection in a domestic cat in the United Kingdom: a case report

Cecilia Gola , Javier Déniz Marrero , Sai Fingerhood , Marta Hernández Pérez , Pablo Díaz Santana

Animal Diseases ›› 2025, Vol. 5 ›› Issue (1) : 12

PDF
Animal Diseases ›› 2025, Vol. 5 ›› Issue (1) : 12 DOI: 10.1186/s44149-025-00163-0
Case Report

Systemic Mycobacterium caprae infection in a domestic cat in the United Kingdom: a case report

Author information +
History +
PDF

Abstract

This report describes the first documented case of Mycobacterium caprae (M. caprae) infection in a domestic cat (Felis catus) in the United Kingdom. The affected cat was a male-castrated Bengal breed that presented with respiratory symptoms and progressive weight loss. Clinical signs were unresponsive to antibiotics and anti-inflammatory therapy. Postmortem examination and histopathology revealed severe chronic pyogranulomatous bronchopneumonia with necrosis and acid-fast bacilli, which were identified as M. capraevia PCR and culture. While primarily a pathogen of goats, M. caprae poses zoonotic risks and requires specialized diagnostics. This case emphasizes the need for interdisciplinary collaboration to address emerging zoonotic threats.

Keywords

Mycobacterium caprae / Domestic cat / Pathology / Pulmonary

Cite this article

Download citation ▾
Cecilia Gola, Javier Déniz Marrero, Sai Fingerhood, Marta Hernández Pérez, Pablo Díaz Santana. Systemic Mycobacterium caprae infection in a domestic cat in the United Kingdom: a case report. Animal Diseases, 2025, 5(1): 12 DOI:10.1186/s44149-025-00163-0

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

AhmadI, KudiCA, AbdulkadirAI, SaiduSNA, ChafeUM, AbdulmalikZ. Survey of bovine tuberculosis in Nigerian beef cattle. Open Vet J., 2018, 84463-470.

[2]

AmatoB, CapucchioTM, BiasibettiE, ManganoE, BoniottiBM, PacciariniLM, MiglioreS, VitaleM, FiasconaroM, PrestiDi Marco Lo, V.. Pathology and genetic findings in a rare case of Mycobacterium caprae infection in a sow. Veterinary Microbiology, 2017, 205: 71-74.

[3]

BayraktarB, TogayA, GencerH, KockayaT, DalgicN, BarisAB, BulutE. Mycobacterium caprae causing lymphadenitis in a child. The Pediatric Infectious Disease Journal, 2011, 30111012-1013.

[4]

Broughan JM, Downs SH, Crawshaw TR, Upton PA, Brewer J, Clifton-Hadley RS. 2013. Mycobacterium bovis infections in domesticated nonbovine mammalian species. Part 1: Review of epidemiology and laboratory submissions in Great Britain 2004–2010. Vet J. 198 (2): 339–45. https://doi.org/10.1016/j.tvjl.2013.09.006.

[5]

Caswell, JL, & Williams, KJ. 2016. Respiratory system (Vol. 2). In Jubb, Kennedy, and Palmer’s Pathology of domestic animals. Elsevier.

[6]

CoutoSS, ArtachoCA. Mycobacterium fortuitum pneumonia in a cat and the role of lipid in the pathogenesis of atypical mycobacterial infections. Veterinary Pathology, 2007, 444543-546.

[7]

Díaz-SantanaP, FernándezA, Díaz-DelgadoJ, VelaAI, DomínguezL, Suárez-SantanaC, Puig-LozanoR, Fernández-MaldonadoC, SierraE, ArbeloM. Nocardiosis in free-ranging cetaceans from the central-Eastern Atlantic Ocean and Contiguous Mediterranean sea. Animals (Basel)., 2022, 124434.

[8]

FernandezJA, HidalgoMN, HodzicE, DiabSS, UzalFA. Pathology of coccidioidomycosis in llamas and alpacas. Journal of Veterinary Diagnostic Investigation, 2018, 304560-564.

[9]

de la Fuente J, Díez-Delgado I, Contreras M, Vicente J, Cabezas-Cruz A, Tobes R, Manrique M, López V, Romero B, Bezos J, et al. 2015. Comparative genomics of field isolates of Mycobacterium bovis and M. caprae provides evidence for possible correlations with bacterial viability and virulence. PLoS Negl Trop Dis. 9 (11): e0004232. https://doi.org/10.1371/journal.pntd.0004232.

[10]

GhielmettiG, GigerU. Mycobacterium avium: An emerging pathogen for dog breeds with hereditary immunodeficiencies. Curr Clin Microbiol Rep., 2020, 7367-80.

[11]

GhielmettiG, ScherrerS, FriedelU, FreiD, SuterD, PerlerL, WittenbrinkMM. Epidemiological tracing of bovine tuberculosis in Switzerland, multilocus variable number of tandem repeat analysis of Mycobacterium bovis and Mycobacterium caprae. PLoS ONE, 2017, 122. e0172474

[12]

Gunn-MooreDA. Feline mycobacterial infections. The Veterinary Journal, 2014, 2012230-238.

[13]

HusainNAThe Lung, 2021In Robbins & Cotran Pathologic Basis of DiseaseElsevier

[14]

Infantes-LorenzoJA, RomeroB, Rodríguez-BertosA, RoyA, OrtegaJ, de JuanL, MorenoI, DomínguezM, DomínguezL, BezosJ. Tuberculosis caused by Mycobacterium caprae in a camel (Camelus dromedarius). BMC Veterinary Research, 2020, 161435.

[15]

Krajewska-WędzinaM, OlechW, KozińskaM, Augustynowicz-KopećE, WeinerM, SzulowskiK. Bovine tuberculosis outbreak in farmed American bison (Bison bison) in Poland. Polish Journal of Veterinary Sciences, 2017, 204819-821.

[16]

LehmannS, DervasE, Ruiz SubiraA, EulenbergerU, GimmelA, GrimmF, HetzelU, KiparA. Verminous pneumonia in European hedgehogs (Erinaceus europaeus). Veterinary Pathology, 2024, 612256-268.

[17]

MaloneKM, GordonSV. Mycobacterium tuberculosis complex members adapted to wild and domestic animals. Advances in Experimental Medicine and Biology, 2017, 1019: 135-154.

[18]

Martínez-LirolaM, HerranzM, Buenestado SerranoS, Rodríguez-GrandeC, Dominguez InarraE, Garrido-CárdenasJA, Correa RuizAM, BermúdezMP, Causse Del RíoM, et al. . One health approach revealed the long-term role of Mycobacterium caprae as the hidden cause of human tuberculosis in a region of Spain from 2003–2022. Eurosurveillance Weekly, 2023, 28122200852.

[19]

MitchellJL, StanleyP, McDonaldK, BurrP, RhodesSG, Gunn-MooreDA, HopeJC. Diagnostic accuracy of the interferon-gamma release assay (IGRA) for cases of feline mycobacteriosis. Preventive Veterinary Medicine, 2021, 193. 105409

[20]

MitchellJL, Del PozoJ, WoolleyCSC, DheendsaR, HopeJC, Gunn-MooreDA. Histological and immunohistochemical features suggest etiological differences in lymph node and (muco)cutaneous feline tuberculosis lesions. Journal of Small Animal Practice, 2022, 633174-187.

[21]

O'HalloranC, Tørnqvist-JohnsenC, WoodsG, MitchellJ, ReedN, BurrP, Gascoyne-BinziD, WeggM, BeardallS, HopeJ, et al. . Feline tuberculosis caused by Mycobacterium bovis infection of domestic UK cats associated with feeding a commercial raw food diet. Transboundary and Emerging Diseases, 2021, 6842308-2320.

[22]

O'ReillyLM, DabornCJ. The epidemiology of Mycobacterium bovis infections in animals and man: A review. Tubercle and Lung Disease, 1995, 76Suppl 11-46.

[23]

PateM, SvaraT, GombacM, PallerT, Zolnir-DovcM, EmersicI, ProdingerWM, BartosM, ZdovcI, KrtB, et al. . Outbreak of tuberculosis caused by Mycobacterium caprae in a zoological garden. Journal of Veterinary Medicine. b, Infectious Diseases and Veterinary Public Health, 2006, 538387-392.

[24]

Reheman, A., Cao, X.J., Wang, Y.F., Nie, X., Cao, G., Zhou, W., Yang, B., Lei, Y.Y., Zhang, W.P., Naeem, M.A., Chen, X., 2023. Involvement of 2′-5′ oligoadenylate synthetase-like protein in the survival of Mycobacterium tuberculosis avirulent strain in macrophages. Animal Diseases 3: 5. https://doi.org/10.1186/s44149-023-00068-w.

[25]

Riopel ND, Long R, Heffernan C, Tyrrell GJ, Shandro C, Li V, Islam MR, Stobart M, Sharma MK, Soualhine H, Cooper R. 2024. Characterization of Mycobacterium orygis, Mycobacterium bovis, and Mycobacterium caprae infections in humans in Western Canada. J Infect Dis. E 124. https://doi.org/10.1093/infdis/jiae124.

[26]

SesterM, SotgiuG, LangeC, GiehlC, GirardiE, MiglioriGB, BossinkA, DhedaK, DielR, DominguezJ, et al. . Interferon-γ release assays for the diagnosis of active tuberculosis: A systematic review and meta-analysis. European Respiratory Journal, 2011, 371100-111.

[27]

SevillaIA, ArnalMC, FuertesM, MartínE, ComengeJ, ElguezabalN, Fernández de LucoD, GarridoJM. Tuberculosis outbreak caused by Mycobacterium caprae on a rabbit farm in Spain. Transboundary and Emerging Diseases, 2020, 671431-441.

[28]

SlavieroM, EhlersLP, ArgentaFF, SaviC, LopesBC, PavariniSP, DriemeierD, SonneL. Causes and lesions of fatal pneumonia in domestic cats. Journal of Comparative Pathology, 2021, 18959-71.

[29]

StingR, SchwabeI, KieferleM, MünchM, RauJ. Fatal Infection in an Alpaca (Vicugna pacos) Caused by Pathogenic Rhodococcus equi. Animals (Basel)., 2022, 12101303.

[30]

VidalE, GrasaM, PerálvarezT, MartínM, MercaderI, Pérez de ValB. Transmission of tuberculosis caused by Mycobacterium caprae between dairy sheep and goats. Small Ruminant Research., 2018, 158: 22-25.

[31]

World Health Organization. 2023. Global Tuberculosis Report 2023. Geneva: World Health Organization. License: CC BY-NC-SA 3.0 IGO.

RIGHTS & PERMISSIONS

The Author(s)

AI Summary AI Mindmap
PDF

195

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/