Gemini Dressing with Both Super-hydrophilicity and -hydrophobicity Pursuing Isolation of Blood Cells for Hemostasis and Wound Healing

Qing Li; Enling Hu; Kun Yu; Ruiqi Xie; Fei Lu; Bitao Lu; Rong Bao; Fangyin Dai; Guangqian Lan

doi:10.1007/s42765-023-00280-w

Advanced Fiber Materials ›› 2023, Vol. 5 ›› Issue (4) : 1447 -1466. DOI: 10.1007/s42765-023-00280-w

Research Article

Gemini Dressing with Both Super-hydrophilicity and -hydrophobicity Pursuing Isolation of Blood Cells for Hemostasis and Wound Healing

Qing Li ¹^,²
, Enling Hu ¹^,²
, Kun Yu ¹^,²
, Ruiqi Xie ¹^,²
, Fei Lu ¹^,²
, Bitao Lu ¹^,²
, Rong Bao ³
, Fangyin Dai ¹^,²^,^h
, Guangqian Lan ¹^,²^,^j

Author information +

¹State Key Laboratory of Silkworm Genome Biology, College of Sericulture Textile and Biomass Science, Southwest University, 400715, Chongqing, China

²Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile, 400715, Chongqing, China

³The Ninth People’s Hospital of Chongqing, No. 69 Jialing Village, BeiBei District, 400715, Chongqing, China

^h fydai@swu.edu.cn

^j j070218@swu.edu.cn

Qing Li

is studying in the School of Sericulture, Textile and Biomass science, Southwest University, majoring in Fibrous materials and Engineering. His main research direction is biomedical hemostatic materials.

Enling Hu

holds a Doctor’s degree from the Hong Kong Polytechnic University. His research interests are the application of high-end medical textiles and nanomaterials in rapid hemostasis and wound healing.

Kun Yu

received a Master’s degree in Fiber Materials and Engineering from Southwest University in 2017. He presided over and participated in a number of NSFC projects. His main research field is the development and application of biomedical materials.

Ruiqi Xie

holds a Doctor’s degree from the Hong Kong Polytechnic University. She is working on the design and regulation mechanism of intelligent medical materials: the design of shape memory materials based on natural polymers and their applications in wound healing and hemostasis.

Fei Lu

received a Doctor’s degree in Materials Science from Tianjin University of Technology in 2013. He is mainly engaged in research on the structure and performance control of natural polymer materials, application research on polymer materials in wound hemostasis and healing, and research and development on biomedical polymer materials.

Bitao Lu

holds a Doctor’s degree from the Southwest University in 2022. His research interests are the application of high-end medical textiles and nanomaterials in rapid hemostasis and wound healing.

Rong Bao

graduated from the Department of Clinical Medicine, Jining Medical University, Shandong Province in 1992, and obtained a master of Medicine in Pathology and pathophysiology from the School of Medicine, Shandong University in 2004. She has been engaged in pathological diagnosis for nearly 30 years, and she is especially good at pathological diagnosis of tumors.

Fangyin Dai

graduated from Southwest Agricultural University, a professor and doctoral supervisor of Southwest University. He has presided over more than 10 national and municipal scientific research projects, such as National 863, National Natural Science Foundation. Principal research projects: 973, 863, 948, more than 20 high-level research projects, such as national key and level projects, National Basic Science and Technology Projects, public welfare industry (agriculture) research projects, and international cooperation key projects. He is currently the director of the State Key Laboratory of Silkworm Genome Biology of Southwest University, the Dean of the School of Sericulture Textile and Biomass Science, and the chief scientist of the national sericulture industry technology system.

Guangqian Lan

is the Vice President of the School of Sericulture, Textile and Biomass Science, Southwest University. He holds a Doctor's degree from Southwest University. Since 2007, he has been committed to the research and development of rapid hemostatic materials and wound healing dressings.

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Abstract

Achieving efficient hemostasis and wound management is vital to preserve life and restore health in case of extensive hemorrhagic skin damage. Here, we develop a filter pump-like hierarchical porous-structure (HPS) dressing based on a non-woven substrate, konjac glucomannan (KGM) aerogel, and bi-functional microporous starch (BMS). The KGM aerogel intercalates into the non-woven network structure, forming a hydrophilic frame to stimulate the plasma permeation toward the interior in synergy with the hydrophilic pores of the BMS. The BMS surface forms a hydrophobic matrix that fills the spaces of the KGM hydrophilic frame, contributing to the isolation and aggregation of blood cells on the surface of the HPS dressing to establish rapid hemostasis. Animal model experiments suggest reliable HPS dressing hemostatic capacity, as it is able to stop ear artery and liver bleeding within 97.6 ± 15.2 s and 67.8 ± 5.4 s, respectively. Furthermore, the dressings exhibit antibacterial properties and enabled wound healing within 2 weeks. In vitro hemolysis and cytotoxicity tests also confirm the biocompatibility of HPS dressings. This novel “two-in-one” hemostatic dressing facilitates tissue repair of bleeding wounds over the entire recovery period, thereby providing a convenient strategy for wound management.

Graphical Abstract

A Gemini HPS dressing for both hemostasis and wound healing was proposed using amphiphilic hierarchical-porous structures to isolate and aggregate blood cells to promote hemostasis, and alloy nanoparticles to inhibit bacterial proliferation to accelerate wound healing.

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Qing Li, Enling Hu, Kun Yu, Ruiqi Xie, Fei Lu, Bitao Lu, Rong Bao, Fangyin Dai, Guangqian Lan. Gemini Dressing with Both Super-hydrophilicity and -hydrophobicity Pursuing Isolation of Blood Cells for Hemostasis and Wound Healing. Advanced Fiber Materials, 2023, 5(4): 1447-1466 DOI:10.1007/s42765-023-00280-w