Temperature-Gated Light-Guiding Hydrogel Fiber for Thermoregulation During Optogenetic Neuromodulation
Guoyin Chen, Siming Xu, Qiangqiang Zhou, Yuejiao Zhang, Yuhan Song, Jing Mi, Yuehua Liu, Kai Hou, Jie Pan
Advanced Fiber Materials ›› 2023, Vol. 5 ›› Issue (3) : 968-978.
Temperature-Gated Light-Guiding Hydrogel Fiber for Thermoregulation During Optogenetic Neuromodulation
With the rise of optogenetic manipulation of neurons, the effects of optogenetic heating on temperature-sensitive physiological processes, and the damage to surrounding tissues have been neglected. This manuscript reports the fabrication of a highly temperature-sensitive semi-interpenetrating optical hydrogel fiber (TSOHF) using the integrated dynamic wet-spinning technique. TSOHF exhibits a structural tunable diameter, clear core/sheath structure, tunable temperature-sensitivity, excellent light propagation property (0.35 dB cm− 1, 650 nm laser light), and good biocompatibility (including tissue-like Young’s modulus, stable dimensional stability, and low cytotoxicity). Based on these properties, a potential application of optogenetic regulation of neural tissue (hypoglossal nerve), with controllable temperature using TSOHF was designed and performed. Further, this work provides new insight into molecular design and a practical approach to continually manufacture a temperature-sensitive hydrogel optical fiber for applications in intelligent photomedicine.
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