Temperature-Gated Light-Guiding Hydrogel Fiber for Thermoregulation During Optogenetic Neuromodulation
Guoyin Chen , Siming Xu , Qiangqiang Zhou , Yuejiao Zhang , Yuhan Song , Jing Mi , Yuehua Liu , Kai Hou , Jie Pan
Advanced Fiber Materials ›› 2023, Vol. 5 ›› Issue (3) : 968 -978.
Temperature-Gated Light-Guiding Hydrogel Fiber for Thermoregulation During Optogenetic Neuromodulation
With the rise of optogenetic manipulation of neurons, the effects of optogenetic heating on temperature-sensitive physiological processes, and the damage to surrounding tissues have been neglected. This manuscript reports the fabrication of a highly temperature-sensitive semi-interpenetrating optical hydrogel fiber (TSOHF) using the integrated dynamic wet-spinning technique. TSOHF exhibits a structural tunable diameter, clear core/sheath structure, tunable temperature-sensitivity, excellent light propagation property (0.35 dB cm− 1, 650 nm laser light), and good biocompatibility (including tissue-like Young’s modulus, stable dimensional stability, and low cytotoxicity). Based on these properties, a potential application of optogenetic regulation of neural tissue (hypoglossal nerve), with controllable temperature using TSOHF was designed and performed. Further, this work provides new insight into molecular design and a practical approach to continually manufacture a temperature-sensitive hydrogel optical fiber for applications in intelligent photomedicine.
the Shanghai Stomatological Hospital Science and Technology Talents Project(SSH-2022-KJCX-B01)
National Key Research and Development Program of China(2021YFA1201302/2021YFA1201300)
China National Postdoctoral Program for Innovative Talents(BX20220063)
Office of GradGraduate Student Innovation Fund of Donghua University(CUSF-DH-D-2020038)
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