Trilayered Fibrous Dressing with Wettability Gradient for Spontaneous and Directional Transport of Massive Exudate and Wound Healing Promotion
Lei Liu, Hengqiu Sun, Jiaming Zhang, Bingjie Xu, Yujie Gao, Dongming Qi, Zhengwei Mao, Jindan Wu
Advanced Fiber Materials ›› 2022, Vol. 5 ›› Issue (2) : 574-587.
Trilayered Fibrous Dressing with Wettability Gradient for Spontaneous and Directional Transport of Massive Exudate and Wound Healing Promotion
Excessive exudate at wound sites increases treatment difficulty and severely decelerates the healing process. In wound exudate management, dressings with unidirectional liquid transport capability have exhibited enormous potential. However, it remains challenging to improve the one-way liquid transport efficiency. Herein, a trilayered fibrous dressing is constructed by sequentially electrospinning polyurethane (PU) and polyvinylidene fluoride (PVDF) onto cotton fabric. Through hot pressing, a stable wettability gradient is formed across the PVDF/PU/cotton dressing due to the melting and bridging of PU nanofibers. The trilayered dressing exhibited rapid unidirectional transport with water penetrating from the hydrophobic side to the hydrophilic side in 6 s. The hydrostatic pressure from the hydrophilic side to the hydrophobic side is 569% higher than that from the hydrophobic side to the hydrophilic side, indicating that the dressing has a profound unidirectional conductivity. In vivo experiments demonstrates that the trilayered dressing can accelerate the wound healing process, especially in the early stages of wound occurrence, by quickly draining the excessive exudate. This study provides a new method to construct wound dressings with wettability gradients, which are advantageous for efficient exudate removal.
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