Antibacterial Electrospun Nanofibrous Materials for Wound Healing

Abstract

One of the leading causes of wound healing delays is bacterial infection, which limits the process of restoring the histological and functional integrity of the skin. Electrospun nanofibrous materials (ENMs) are biocompatible and biodegradable, and they can provide specific physical, chemical, and biological cues to accelerate wound healing. Based on this fact, a series of multifunctional ENMs for complex clinical applications, particularly infected skin injuries, have been developed. Antibiotics, antimicrobial peptides (AMPs), metals and metal oxides (MMOs), and antibacterial polymers have previously been incorporated into ENMs through advanced material processing techniques, endowing ENMs with enhanced and excellent antibacterial activity. This review summarizes wound healing issues and provides recent advances in antibacterial ENMs created by cutting-edge technology. The future of clinical and translational research on ENMs is also discussed.

Graphical Abstract

Funding

the Improvement Project for Theranostic Ability on Difficulty Miscellaneous Disease (Tumor) from National Health Commission of China(ZLYNXM202006); the Chinese Central Special Fund for Local Science and Technology Development of Hubei Province(2018ZYYD023); the Science and Technology Department of Hubei Province Key Project(2018ACA159); National Postdoctoral Program for Innovative Talents(BX20220240)