Photothermal-Triggered Structural Change of Nanofiber Scaffold Integrating with Graded Mineralization to Promote Tendon–Bone Healing

Chenghao Yu; Tianrui Wang; Hongcui Diao; Na Liu; Yi Zhang; Hongyuan Jiang; Peng Zhao; Zhengyi Shan; Zewen Sun; Tong Wu; Xiumei Mo; Tengbo Yu

doi:10.1007/s42765-022-00154-7

Advanced Fiber Materials ›› 2022, Vol. 4 ›› Issue (4) : 908 -922. DOI: 10.1007/s42765-022-00154-7

Research Article

Photothermal-Triggered Structural Change of Nanofiber Scaffold Integrating with Graded Mineralization to Promote Tendon–Bone Healing

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¹Department of Sports Medicine, Affiliated Hospital of Qingdao University, 266061, Qingdao, Shandong, China

²Institute of Neuroregeneration and Neurorehabilitation, Qingdao Medical College, Qingdao University, 266071, Qingdao, Shandong, China

³Shandong Key Laboratory of Textile Materials for Healthcare, Collaborative Innovation Center for Eco-Textiles of Shandong Province and the Ministry of Education, 308 Ningxia Road, 266071, Qingdao, Shandong, China

⁴State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 201620, Shanghai, China

⁵Department of Endocrinology, Jinan Central Hospital Affiliated To Shandong University, No. 105 Jiefang Road, 250013, Jinan, Shandong, China

^k twu@qdu.edu.cn

ⁿ ytb8912@hotmail.com

Chenghao Yu

has been a Ph.D. candidate in Clinical Medicine at Qingdao University from 2021 with Prof. Tengbo Yu. He has been working in Prof. Tong Wu’s group at Qingdao University from 2020 as a jointly-supervised student. His research interests include the design and fabrication of electrospun nanofiber scaffolds and their use in tendon-to-bone healing.

Tong Wu

received her Ph.D. in Biomaterials Science from Donghua University in 2018 with Prof. Xiumei Mo. She worked in Prof. Younan Xia’s group at the Georgia Institute of Technology from 2016 as a jointly-supervised Ph.D. candidate and then as a postdoctoral fellow until the end of 2019. She is now working as a professor at the medical college of Qingdao University. Her research interests include the development of novel nanomaterials for biomedical, environmental and energy-related applications.

Xiumei Mo

has held the professor position in Biomaterials at Donghua University since 2004. From 1997 to 2004, she had been a Postdoc fellow in Kyoto University, research fellow in National University of Singapore, and visiting professor in Aachen University. She has been a Committee Member of China Biomaterials Society and Vice Chairman of China Composite Materials Society Super-fine Fiber Branch since 2012. She has got the Science Technical Invention Awards from Shanghai Municipality in 2008, Science and Technology Progress Awards from State Department of People’s Republic of China in 2009, and Nature Science Awards from Shanghai Government in 2015.

Tengbo Yu

obtained his Ph.D. in 2008 from Army Medical University. He is now working as a professor, chief physician, and director of the Knee Protection Department at Qingdao University Affiliated Hospital. He is also the vice president of Qingdao University Affiliated Hospital. His current research interests include tendon-bone healing, cartilage damage and repair, and osteoarthritis treatment.

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Abstract

Scaffolds functionalized with graded changes in both fiber alignment and mineral content are more appealing for tendon-bone healing. This study reports the healing of rotator cuff injury using a heterogeneous nanofiber scaffold, which is associated with a structural gradating from aligned to random and an increasing gradient of mineral content in the same orientation. The photothermal-triggered structural change of a nanofiber scaffold followed by graded mineralization is key to constructing such scaffolds. This type of scaffold was found to be biocompatible and provide beneficial contact guidance in the manipulation of tendon-derived stem cell morphologies in vitro. Specifically, tenogenic and osteogenic differentiation of tendon-derived stem cells were simultaneously achieved using the fabricated scaffold. In vivo investigation also showed the improved healing of rabbit rotator cuff injuries based on immunohistochemical analysis and biomechanical investigation that indicates the promising potential of a dual-gradient nanofiber scaffold in clinical tendon-bone healing.

Graphical abstract

Dual-gradient nanofiber scaffold with transitions in both surface structure and mineral content was designed and manufactured to replicate the native interface between tendon and bone to facilitate the tendon-bone healing in a rabbit rotator cuff injury model.

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Chenghao Yu, Tianrui Wang, Hongcui Diao, Na Liu, Yi Zhang, Hongyuan Jiang, Peng Zhao, Zhengyi Shan, Zewen Sun, Tong Wu, Xiumei Mo, Tengbo Yu. Photothermal-Triggered Structural Change of Nanofiber Scaffold Integrating with Graded Mineralization to Promote Tendon–Bone Healing. Advanced Fiber Materials, 2022, 4(4): 908-922 DOI:10.1007/s42765-022-00154-7