ROS-Scavenging Electroactive Polyphosphazene-Based Core–Shell Nanofibers for Bone Regeneration

Yiqian Huang; Zhiyun Du; Ke Li; Wei Jing; Pengfei Wei; Bo Zhao; Yingjie Yu; Qing Cai; Xiaoping Yang

doi:10.1007/s42765-022-00153-8

Advanced Fiber Materials ›› 2022, Vol. 4 ›› Issue (4) : 894 -907. DOI: 10.1007/s42765-022-00153-8

Research Article

ROS-Scavenging Electroactive Polyphosphazene-Based Core–Shell Nanofibers for Bone Regeneration

Yiqian Huang ¹^,²
, Zhiyun Du ¹^,³
, Ke Li ¹
, Wei Jing ²^,³
, Pengfei Wei ²
, Bo Zhao ²^,^f
, Yingjie Yu ¹^,^g
, Qing Cai ¹^,^h
, Xiaoping Yang ¹^,³

Author information +

¹State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, 100029, Beijing, China

²Beijing Biosis Healing Biological Technology Co., Ltd, 102629, Beijing, China

³Foshan (Southern China) Institute for New Materials, 528200, Foshan, Guangdong, China

^f zhaobo@biosishealing.com

^g yuyingjie@mail.buct.edu.cn

^h caiqing@mail.buct.edu.cn

Yiqian Huang

is currently working at Beijing Biosis Healing Biological Technology Co., Ltd. for bioabsorbable tissue adhesives and biomedical translation. He received his Ph.D. in Materials Science and Engineering from Beijing University of Chemical Technology (BUCT) in 2021. On pursuing his academic career, his research focuses on synthetic polyphosphazene and multi-functionalization for bone regeneration.

Bo Zhao

is a professor and working as CEO at Beijing Biosis Healing Biological Technology Co., Ltd.. He received his Ph.D. in Surgery in 2010 from Capital Medical University. Dr. Zhao has worked on gastrointestinal surgery for over ten years, ranging from gastrointestinal tumors and extracellular matrix, and his research focuses on the small intestine submucosa (SIS).

Yingjie Yu

is an associate professor in the College of Materials Science and Engineering at Beijing University of Chemical Technology (BUCT). He received his Ph.D. from the State University of New York at Stony Brook in 2016, majoring in Materials Science and Engineering. His research interest is in drug delivery system and tissue engineering.

Qing Cai

is a full professor in the College of Materials Science and Engineering at BUCT. She received her Ph.D. in polymer chemistry and physics in 2003 from the Institute of Chemistry, Chinese Academy of Sciences, and has worked at BUCT from then on. Prof. Cai has extensive experience with biodegradable polymers, biocomposites, tissue engineering, and drug delivery, particularly with bone regeneration and dental restoration.

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Abstract

Bone defects are always accompanied by inflammation due to excessive reactive oxygen species (ROS) in injured regions, which greatly impedes the regeneration of bone tissues. Although many conductive polymers have been developed to scavenge ROS, they are typically non-degradable under physiological conditions, making them unsuitable for in vivo applications. Biodegradable polyorganophosphazenes (POPPs) may serve as potent ROS-scavenging biomaterials owing to their versatile chemical structures and ease of functionalization. Herein, a PATGP-type electroactive polyphosphazene with side groups of aniline tetramer and glycine ethyl ester was compared to conventional poly(lactic-co-glycolic acid) (PLGA) in regenerating bone tissues. To conduct in vitro and in vivo evaluations, three kinds of electrospun nanofibrous meshes were prepared: PLGA, PLGA/PATGP blend, and PLGA/PATGP core–shell nanofibers. Among them, PLGA/PATGP core–shell nanofibers outperform the blend and PLGA nanofibers in terms of scavenging ROS, promoting osteogenic differentiation, and accelerating neo-bone formation. The continuous PATGP shell on the PLGA/PATGP core–shell nanofiber surface could apparently provide more significant modulation effects on cellular behaviors than the PLGA/PATGP blend nanofibers with PATGP dispersed in the PLGA matrix. Therefore, the core–shell structured PLGA/PATGP nanofibers were envisioned as a promising candidate scaffold for bone tissue engineering. Additionally, the core–shell design paved the way for biomedical applications of functional POPPs in combination with other polymeric biomaterials, without phase separation or difficulty of increasing the molecular weights of POPPs.

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Yiqian Huang, Zhiyun Du, Ke Li, Wei Jing, Pengfei Wei, Bo Zhao, Yingjie Yu, Qing Cai, Xiaoping Yang. ROS-Scavenging Electroactive Polyphosphazene-Based Core–Shell Nanofibers for Bone Regeneration. Advanced Fiber Materials, 2022, 4(4): 894-907 DOI:10.1007/s42765-022-00153-8