Batch Preparation and Characterization of Electrospun Porous Polylactic Acid-Based Nanofiber Membranes for Antibacterial Wound Dressing

Abstract

A good wound dressing needs to promote wound healing and tissue repair when the skin is injured. In this study, a self-made spherical section free surface electrospinning device was used to produce large quantities of electrospun porous polylactic acid (PLA)/chitosan (CS)/aloin nanofiber membranes (NFMs) for antibacterial wound dressing. The porous structures of PLA-based nanofibers were controlled by adjusting the weight ratios of mixed solvent and solute. The results showed that high-quality porous PLA/CS/aloin (PCA) NFMs were obtained when the weight ratios of chloroform/N, N-dimethylformamide and PLA: CS were 90/10 and 7:1, respectively. The porous PCA NFMs exhibited high porosity, acceptable mechanical properties, moderate hydrophobicity, good swelling property, and high water vapor transmission rate. Moreover, they also showed excellent blood coagulative, antibacterial, biocompatible properties, which had the potential to be used in the application of antibacterial wound dressings.

Funding

National Natural Science Foundation of China(11672198)

Jiangsu Higher Education Institutions of China(20KJA130001)

Six Talent Peaks Project of Jiangsu Province(GDZB-050)

A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions