Coordination of Copper Ion Crosslinked Composite Beads with Enhanced Toxins Adsorption and Thin-Film Nanofibrous Composite Membrane for Realizing the Lightweight Hemodialysis

Abstract

In this study, a novel copper ion (Cu²⁺) crosslinked composites beads with components of sodium alginate (SA) as gel matrix and UiO-66-(COOH)₂ metal organic framework (MOF) nanoparticle as functional filler could effectively adsorb toxins in dialysate. The maximum adsorption capacity of the optimized composite beads (Cu-SA/U-4) for creatinine reached 125.0 mg/g with a positive synergistic effect based on Langmuir isotherm model and pseudo-second-order kinetic model, which was 1.75 times and 1.50 times that of single component beads (Cu-SA) and UiO-66-(COOH)₂ nanoparticle respectively. Furthermore, when the dialysis performance using thin-film nanofibrous composite (TFNC) membrane was comparable, introduction of Cu-SA/U-4 beads into the dialysate allowed the volume of dialysate reduced to one-tenth of that without beads. Therefore, the coordination of such highly efficient adsorbent beads and TFNC dialysis membrane can economize the usage of the dialysate and contributes to realize lightweight hemodialysis. More importantly, we not only prepared a kind of composite bead via carefully designed strategy, but also proposed widely applicable idea of using adsorbents in combination with dialysis membrane to realize lightweight or miniaturized hemodialysis.

Funding

Fundamental Research Funds for the Central Universities(2232020A-04); Natural Science Foundation of Shanghai(19ZR1401300)