Physicochemical and in Vitro Antibacterial Evaluation of Metronidazole Loaded Eudragit S-100 Nanofibrous Mats for the Intestinal Drug Delivery

Priyanka P. Rade; Prabhanjan S. Giram; Ajinkya A. Shitole; Neeti Sharma; Baijayantimala Garnaik

doi:10.1007/s42765-021-00090-y

Advanced Fiber Materials ›› 2021, Vol. 4 ›› Issue (1) : 76 -88. DOI: 10.1007/s42765-021-00090-y

Research Article

Physicochemical and in Vitro Antibacterial Evaluation of Metronidazole Loaded Eudragit S-100 Nanofibrous Mats for the Intestinal Drug Delivery

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¹Polymer Science and Engineering Division, CSIR- National Chemical Laboratory, 411008, Pune, India

²Academy of Scientific and Innovative Research (AcSIR), 201002, Ghaziabad, India

³Symbiosis School of Biological Sciences, Symbiosis International (Deemed University), 412115, Pune, India

^e b.garnaik@ncl.res.in

Dr. Priyanka Prakash Rade

received her B. Tech and M. Tech in Plastics and Polymer Technology from North Maharashtra University, Jalgaon, India. She joined as JRF (DST-INSPIRE, India) in Polymer Science and Engineering Division under the supervision of Dr. (Mrs.) Baijayantimala Garnaik at CSIR-National Chemical Laboratory, Pune, India. Her current research focuses on biodegradable polymers, biocompatible polymers and their use in biomedical applications.

Dr. Prabhanjan Shridhar Giram

received his Ph. D. from CSIR-National chemical laboratory, Pune, under the guidance of Dr. Baijayantimala Garnaik. He joined as a Junior Research Fellow (UGC) and also, he was deputed as a Newton Bhabha fellow to work at king’s college London, UK, during his Ph. D tenure. He received Eudragit®2018 award from Evonik health care Germany. Currently, he is teaching as Assistant Professor in Dr. DPU Pharmacy, Pune. He has gathered experience in biocompatible, biodegradable polymer synthesis, rationalized design of nanoformulation, nanofiber, semisolid dosage form such as ointment, creams, and gel. His career focus is to continue interdisciplinary research such as nanotechnology, tissue engineering, and pharmacy using polymers which will provide pertinent solutions to healthcare.

Dr. Ajinkya Shitole

received Ph.D. from Symbiosis International University, India under guidance of Dr. Neeti Sharma. His areas of expertise are Biomaterials, Tissue Engineering, and Drug Delivery. He has experience in nanofabrication, physicochemical characterization, and biocompatibility evaluation of biomaterials intended for tissue engineering applications. He is skilled in formulation and evaluation of polymeric nano-vesicles for drug delivery applications. Currently, Dr. Ajinkya is working as Medical devices consultant (EU MDR regulatory compliance) at Tata Elxsi, Pune, India.

Dr. Neeti Sharma

holds a Master’s Degree in Biochemistry (Gold Medalist) from University of Lucknow and Doctorate degree in Biotechnology from the University of Pune. During her doctorate tenure as a CSIR fellow at National Centre for Cell Science (NCCS), Pune, she devoted her research to understand the genetic basis and molecular mechanisms of rare genetic syndrome (Rubinstein-Taybi Syndrome). Her areas of expertise lies in Cancer Biology, Nanochemoprevention and Epigentics.

Dr. (Mrs.) Baijayantimala Garnaik

received her Ph.D. from Indian Institute of Technology, Kharagpur, India, Post Doc as a UNESCO fellow (Tokyo Institute of Technology, Tokyo, Japan), visited Austria, and France. Presently, she is pursuing her research career in polymer science and engineering division and teaching as a senior principal scientist and professor at CSIR-National Chemical Laboratory, Pune-411008, Maharashtra, India. Her research area highlights design of novel biocompatible catalysts and synthesis of biocompatible, biodegradable, architectured PLA based polymers, nanofabrication of drug loaded electrospun nanofibrous mat, nanoparticles for healthcare.

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Abstract

Abstract

Metronidazole (MTZ) loaded Eudragit S-100 (ES-100) nonwoven nanofibrous mats were successfully electrospun and evaluated for intestinal drug delivery. MTZ was varied in the range of 1–15% (w/w) in ES-100 nanofibrous mats, the morphological characterization of nanofibrous mats was carried out using FE-SEM and the average diameter of nanofiber was found in the range 150–600 nm. WAXD and DSC demonstrated the amorphous nature of MTZ in ES-100 nanofibrous mats. Their contact angle analysis confirmed the hydrophobic nature. The mechanical strength of ES-100 nanofibrous mats decreased with increasing MTZ concentration. The drug release profiles showed 74% MTZ release from ES-100d within 2 h at pH 6.8 which is the colonic environment. Antibacterial activities against gram-positive bacteria (Staphylococcus aureus) and gram-negative bacteria (Escherichia coli) showed that the ES-100 nanofibrous mats loaded with MTZ exhibited good activity.

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Priyanka P. Rade, Prabhanjan S. Giram, Ajinkya A. Shitole, Neeti Sharma, Baijayantimala Garnaik. Physicochemical and in Vitro Antibacterial Evaluation of Metronidazole Loaded Eudragit S-100 Nanofibrous Mats for the Intestinal Drug Delivery. Advanced Fiber Materials, 2021, 4(1): 76-88 DOI:10.1007/s42765-021-00090-y

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Funding

Department of Science and Technology, Ministry of Science and Technology(Department of Science and Technology, New Delhi, India for the award of DST-INSPIRE fellowship (IF160594))

Indo-French Centre for the Promotion of Advanced Research(LIA MUSCAT)