Construction of Electrospun Organic/Inorganic Hybrid Nanofibers for Drug Delivery and Tissue Engineering Applications

Wei Huang; Yunchao Xiao; Xiangyang Shi

doi:10.1007/s42765-019-00007-w

Advanced Fiber Materials ›› 2019, Vol. 1 ›› Issue (1) : 32 -45. DOI: 10.1007/s42765-019-00007-w

Review

Construction of Electrospun Organic/Inorganic Hybrid Nanofibers for Drug Delivery and Tissue Engineering Applications

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¹State Key Laboratory for Modifcation of Chemical Fibers and Polymer Materials, International Joint Laboratory for Advanced Fiber and Low-dimension Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 201620, Shanghai, People’s Republic of China

²CQM-Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390, Funchal, Portugal

^c xshi@dhu.edu.cn

Wei Huang

received his Master degree in physical chemistry from Wuhan Textile University, Wuhan, China. He is currently a Ph.D. candidate in nanochemistry at the University of Madeira, Funchal, Portugal. His research interests include electrospinning, biomaterials and tissue engineering.

Yunchao Xiao

obtained his master degree in textile materials and design from Taiyuan University of Technology. Currently, he is a Ph.D. candidate in the College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, supervised by Professor Xiangyang Shi. Yunchao Xiao’s current research project is focused on multifunctional nanofiber-based platform for biomedical applications.

Xiangyang Shi

obtained his Ph.D. degree in 1998 from the Chinese Academy of Sciences. From 2002–2008, he was appointed as a research fellow, research associate II, research investigator, and research assistant professor in Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor. In September 2008, he joined Donghua University as a full professor. Since 2010, he has also been appointed as an invited chair in nanotechnology in University of Madeira, Portugal. He has published 334 peer-reviewed SCI-indexed journal articles. His current research interests are focused on dendrimer-based nanomedicine for drug discovery, molecular imaging, and theranostics of cancer, and electrospun polymer nanofiber-based technology for biomedical applications.

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Abstract

Abstract

Electrospun nanofibers hold a great potential in biomedical applications due to their advantages of large specific surface area, good biocompatibility, easy fabrication and surface modification. In particular, organic/inorganic hybrid nanofibers exhibit enhanced mechanical properties and long-term sustained release or controlled release profile of encapsulated drugs, which enables hybrid nanofibers to serve as desired platform for drug delivery and tissue engineering applications. This review summarizes the recent progresses in the preparation, performances and applications of hybrid nanofibers as drug delivery vectors for antibacterial and antitumor therapy, and as nanofibrous scaffolds for bone tissue engineering or other types of tissue engineering applications. Nanofibers doped with various types of inorganic nanoparticles (e.g., halloysite, laponite^®, nano-hydroxyapatite, attapulgite, carbon nanotubes, and graphene, etc.) are introduced and summarized in detail. Future perspectives are also briefly discussed.

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Wei Huang, Yunchao Xiao, Xiangyang Shi. Construction of Electrospun Organic/Inorganic Hybrid Nanofibers for Drug Delivery and Tissue Engineering Applications. Advanced Fiber Materials, 2019, 1(1): 32-45 DOI:10.1007/s42765-019-00007-w