Effects of xenotransplantation of neural stem progenitor cells isolated from «olfactory epithelium» on the functional activity of the retina after ischemia modeled

E. V. Chentsova; I. T. Kuprashvili; M. V. Zueva; I. V. Tsapenko; I. N. Saburina; V. S. Repin; A. V. Revishchin

doi:10.23868/gc134119

Genes & Cells ›› 2007, Vol. 2 ›› Issue (4) : 47 -51. DOI: 10.23868/gc134119

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Effects of xenotransplantation of neural stem progenitor cells isolated from «olfactory epithelium» on the functional activity of the retina after ischemia modeled

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Abstract

Neural stem/ progenitor cells [NSPCs] isolated from the olfactory area of human nasal mucosa are considered as one of the most promising sources for autologous material in cellular therapy and tissue engineering.

Xenotransplantation of NSPCs was performed in rabbits with ischemia retinae caused by laser coagulation of retina vessels of the l-II class. The cells were introduced into suprachoroldal space. Electroretinographic studies were done to evaluate the extent and degree of functional activity changes of the retina and functional reparative effects of transplantation.

According to electroretinography single transplantation of NSPCs promotes the maintenance and recovery of the retinal function in modelled acute ischemia retinae that correlates with the results of ophthalmoscopy done.

Transplantation of neural stem progenitor cells into suprachoroldal space has been shown to be a safe and effective method of introduction of cells in order to treat retinal disorders due to ischemia.

Keywords

neural stem cells / neurotransplantation / «olfactory epithelium» / ischemia retinae

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E. V. Chentsova, I. T. Kuprashvili, M. V. Zueva, I. V. Tsapenko, I. N. Saburina, V. S. Repin, A. V. Revishchin. Effects of xenotransplantation of neural stem progenitor cells isolated from «olfactory epithelium» on the functional activity of the retina after ischemia modeled. Genes & Cells, 2007, 2(4): 47-51 DOI:10.23868/gc134119

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